A possible role of chemotaxis in germinal center formation

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dc.creatorBeyer, Tilo
dc.creatorMeyer-Hermann, Michael
dc.creatorSoff, Gerhard
dc.date2002-06-11
dc.date.accessioned2026-07-07T05:47:40Z
dc.date.available2026-07-07T05:47:40Z
dc.descriptionDuring the germinal center reaction a characteristic morphology is developed. In the framework of a recently developed space-time-model for the germinal center a mechanism for the formation of dark and light zones has been proposed. The mechanism is based on a diffusing differentiation signal which is secerned by follicular dendritic cells. Here, we investigate a possible influence of recently found chemokines for the germinal center formation in the framework of a single-cell-based stochastic and discrete three-dimensional model. We will also consider alternative possible chemotactic pathways that may play a role for the development of both zones. Our results suggest that the centrocyte motility resulting from a follicular dendritic cell-derived chemokine has to exceed a lower limit to allow the separation of centroblasts and centrocytes. In contrast to light microscopy the dark zone is ring shaped. This suggests that FDC-derived chemoattractants alone cannot explain the typical germinal center morphology.
dc.description27 pages, 8 figures, 76 references
dc.identifierhttps://arxiv.org/abs/physics/0206026
dc.identifierhttp://arxiv.org/abs/physics/0206026
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/84741
dc.subjectBiological Physics
dc.subjectQuantitative Biology
dc.titleA possible role of chemotaxis in germinal center formation
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