Fluctuation-Driven Molecular Transport in an Asymmetric Membrane Channel

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dc.creatorKosztin, Ioan
dc.creatorSchulten, Klaus
dc.date2004-10-27
dc.date.accessioned2026-07-07T05:53:14Z
dc.date.available2026-07-07T05:53:14Z
dc.descriptionChannel proteins, that selectively conduct molecules across cell membranes, often exhibit an asymmetric structure. By means of a stochastic model, we argue that channel asymmetry in the presence of non-equilibrium fluctuations, fueled by the cell's metabolism as observed recently, can dramatically influence the transport through such channels by a ratchet-like mechanism. For an aquaglyceroporin that conducts water and glycerol we show that a previously determined asymmetric glycerol potential leads to enhanced inward transport of glycerol, but for unfavorably high glycerol concentrations also to enhanced outward transport that protects a cell against poisoning.
dc.descriptionREVTeX4, 4 pages, 3 figures; Accepted for publication in Phys. Rev. Lett
dc.identifierhttps://arxiv.org/abs/physics/0410254
dc.identifierhttp://arxiv.org/abs/physics/0410254
dc.identifierPhys. Rev. Lett. 93, 238102 (2004)
dc.identifierdoi:10.1103/PhysRevLett.93.238102
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/86571
dc.subjectBiological Physics
dc.subjectStatistical Mechanics
dc.subjectBiomolecules
dc.titleFluctuation-Driven Molecular Transport in an Asymmetric Membrane Channel
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