An efficient strategy to characterize alleles and complex haplotypes using DNA-markers
| dc.creator | Labouriau, Rodrigo | |
| dc.creator | Sørensen, Poul | |
| dc.creator | Juul-Madsen, Helle R. | |
| dc.date | 2008-04-10 | |
| dc.date.accessioned | 2026-07-07T09:31:34Z | |
| dc.date.available | 2026-07-07T09:31:34Z | |
| dc.description | We consider the problem of detecting and estimating the strength of association between a trait of interest and alleles or haplotypes in a small genomic region (e.g. a gene or a gene complex), when no direct information on that region is available but the values of neighbouring DNA-markers are at hand. We argue that the effects of the non-observable haplotypes of the genomic regions can and should be represented by factors representing disjoint groups of marker-alleles. A theoretical argument based on a hypothetical phylogenetic tree supports this general claim. The techniques described allow to identify and to infer the number of detectable haplotypes in the genomic region that are associated with a trait. The methods proposed use an exhaustive combinatorial search coupled with the maximization of a version of the likelihood function penalized for the number of parameters. This procedure can easily be implemented with standard statistical methods for a moderate number of marker-alleles. | |
| dc.description | 21 pages, 7 figures | |
| dc.identifier | https://arxiv.org/abs/0804.1690 | |
| dc.identifier | http://arxiv.org/abs/0804.1690 | |
| dc.identifier.uri | http://salesiana.dossiersoluciones.com/handle/123456789/158501 | |
| dc.subject | Applications | |
| dc.subject | Genomics | |
| dc.title | An efficient strategy to characterize alleles and complex haplotypes using DNA-markers | |
| dc.type | text |