Dynamics of a stiff biopolymer in an actively contractile background: buckling, stiffening and negative dissipation

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dc.creatorKikuchi, Norio
dc.creatorEhrlicher, Allen
dc.creatorKoch, Daniel
dc.creatorKäs, Josef A.
dc.creatorRamaswamy, Sriram
dc.creatorRao, Madan
dc.date2009-01-26
dc.date.accessioned2026-07-07T12:34:47Z
dc.date.available2026-07-07T12:34:47Z
dc.descriptionWe present a generic theory for the dynamics of a stiff filament under tension, in an active medium with orientational correlations, such as a microtubule in contractile actin. In sharp contrast to the case of a passive medium, we find the filament can stiffen, and possibly oscillate, \textit{or} buckle, depending on the contractile or tensile nature of the activity \textit{and} the filament-medium anchoring interaction. We present experiments on the behaviour of microtubules in the growth cone of a neuron, which provide evidence for these apparently opposing behaviours. We also demonstrate a strong violation of the fluctuation-dissipation (FD) relation in the effective dynamics of the filament, including a negative FD ratio. Our approach is also of relevance to the dynamics of axons, and our model equations bear a remarkable formal similarity to those in recent work [PNAS (2001) {\bf 98}:14380-14385] on auditory hair cells. Detailed tests of our predictions can be made using a single filament in actomyosin extracts or bacterial suspensions.
dc.description6 pages, 3 eps figures
dc.identifierhttps://arxiv.org/abs/0901.4126
dc.identifierhttp://arxiv.org/abs/0901.4126
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/217559
dc.subjectSoft Condensed Matter
dc.titleDynamics of a stiff biopolymer in an actively contractile background: buckling, stiffening and negative dissipation
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