Robust formation of morphogen gradients

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dc.creatorBollenbach, T.
dc.creatorKruse, K.
dc.creatorPantazis, P.
dc.creatorGonzález-Gaitán, M.
dc.creatorJülicher, F.
dc.date2004-12-08
dc.date.accessioned2026-07-07T05:58:48Z
dc.date.available2026-07-07T05:58:48Z
dc.descriptionWe discuss the formation of graded morphogen profiles in a cell layer by nonlinear transport phenomena, important for patterning developing organisms. We focus on a process termed transcytosis, where morphogen transport results from binding of ligands to receptors on the cell surface, incorporation into the cell and subsequent externalization. Starting from a microscopic model, we derive effective transport equations. We show that, in contrast to morphogen transport by extracellular diffusion, transcytosis leads to robust ligand profiles which are insensitive to the rate of ligand production.
dc.identifierhttps://arxiv.org/abs/q-bio/0412014
dc.identifierhttp://arxiv.org/abs/q-bio/0412014
dc.identifierPhysical Review Letters 94, 018103 (2005)
dc.identifierdoi:10.1103/PhysRevLett.94.018103
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/88496
dc.subjectOther Quantitative Biology
dc.subjectBiological Physics
dc.titleRobust formation of morphogen gradients
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