Multiple, weak hits confuse complex systems: A transcriptional regulatory network as an example

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dc.creatorAgoston, Vilmos
dc.creatorCsermely, Peter
dc.creatorPongor, Sandor
dc.date2004-10-21
dc.date2005-06-11
dc.date.accessioned2026-07-07T05:58:42Z
dc.date.available2026-07-07T05:58:42Z
dc.descriptionRobust systems, like the molecular networks of living cells are often resistant to single hits such as those caused by high-specificity drugs. Here we show that partial weakening of the Escherichia coli and Saccharomyces cerevisiae transcriptional regulatory networks at a small number (3-5) selected nodes can have a greater impact than the complete elimination of a single selected node. In both cases, the targeted nodes have the greatest possible impact; still the results suggest that in some cases broad specificity compounds or multitarget drug therapies may be more effective than individual high-affinity, high-specificity ones. Multiple but partial attacks mimic well a number of in vivo scenarios and may be useful in the efficient modification of other complex systems.
dc.description8 pages, 3 figures, 2 tables
dc.identifierhttps://arxiv.org/abs/q-bio/0410026
dc.identifierhttp://arxiv.org/abs/q-bio/0410026
dc.identifierPhys. Rev. E 71, 051909 (2005)
dc.identifierdoi:10.1103/PhysRevE.71.051909
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/88458
dc.subjectMolecular Networks
dc.subjectGenomics
dc.titleMultiple, weak hits confuse complex systems: A transcriptional regulatory network as an example
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