Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth

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The mechanism of suberoylanilide hydroxamic acid in cell growth inhibition involved induction of pRb-2/p130 interaction and nuclear translocation with E2F-4, followed by significant repression in E2F-1 and PCNA nuclear levels, which led to inhibition in DNA synthesis in mammary epithelial cell lines.

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http://salesiana.dossiersoluciones.com/handle/123456789/150

Consulte el texto completo en el siguiente enlace:

https://pmc.ncbi.nlm.nih.gov/articles/PMC13923/
 https://pubmed.ncbi.nlm.nih.gov/11250759/
 https://doi.org/10.1186/bcr284

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PubMed Central