Selection for Fitness vs. Selection for Robustness in RNA Secondary Structure Folding

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dc.creatorWilke, Claus O.
dc.date2001-03-09
dc.date.accessioned2026-07-07T05:45:33Z
dc.date.available2026-07-07T05:45:33Z
dc.descriptionWe investigate the competition between two quasispecies residing on two disparate neutral networks. Under the assumption that the two neutral networks have different topologies and fitness levels, it is the mutation rate that determines which quasispecies will eventually be driven to extinction. For small mutation rates, we find that the quasispecies residing on the neutral network with the lower replication rate will disappear. For higher mutation rates, however, the faster replicating sequences may be outcompeted by the slower replicating ones in case the connection density on the second neutral network is sufficiently high. Our analytical results are in excellent agreement with flow-reactor simulations of replicating RNA sequences.
dc.description15 pages Latex, 6 figures
dc.identifierhttps://arxiv.org/abs/physics/0103022
dc.identifierhttp://arxiv.org/abs/physics/0103022
dc.identifierEvolution 55:2412-2420, 2001
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/84031
dc.subjectBiological Physics
dc.subjectStatistical Mechanics
dc.subjectAdaptation and Self-Organizing Systems
dc.subjectPopulations and Evolution
dc.titleSelection for Fitness vs. Selection for Robustness in RNA Secondary Structure Folding
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