Directionality of glioblastoma invasion in a 3d in vitro experiment

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dc.creatorStein, A M
dc.creatorVader, D A
dc.creatorDeisboeck, T S
dc.creatorChiocca, E A
dc.creatorSander, L M
dc.creatorWeitz, D A
dc.date2006-10-17
dc.date.accessioned2026-07-07T07:30:10Z
dc.date.available2026-07-07T07:30:10Z
dc.descriptionGlioblastoma is the most malignant form of brain cancer. It is extremely invasive; the mechanisms that govern invasion are not well understood. To better understand the process of invasion, we conducted an in vitro experiment in which a 3d tumour spheroid is implanted into a collagen gel. The paths of individual invasive cells were tracked. These cells were modeled as radially biased, persistent random walkers. The radial velocity bias was found to be 20 microns/hr on day one, but decayed significantly by day two. The cause of this bias is thought to be due to chemotactic factors and contact guidance along collagen fibers.
dc.identifierhttps://arxiv.org/abs/q-bio/0610031
dc.identifierhttp://arxiv.org/abs/q-bio/0610031
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/118373
dc.subjectCell Behavior
dc.titleDirectionality of glioblastoma invasion in a 3d in vitro experiment
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