An Unusual 500,000 Bases Long Oscillation of Guanine and Cytosine Content in Human Chromosome 21
| dc.creator | Li, Wentian | |
| dc.creator | Holste, Dirk | |
| dc.date | 2004-11-03 | |
| dc.date.accessioned | 2026-07-07T06:29:42Z | |
| dc.date.available | 2026-07-07T06:29:42Z | |
| dc.description | An oscillation with a period of around 500 kb in guanine and cytosine content (GC%) is observed in the DNA sequence of human chromosome 21. This oscillation is localized in the rightmost one-eighth region of the chromosome, from 43.5 Mb to 46.5 Mb. Five cycles of oscillation are observed in this region with six GC-rich peaks and five GC-poor valleys. The GC-poor valleys comprise regions with low density of CpG islands and, alternating between the two DNA strands, low gene density regions. Consequently, the long-range oscillation of GC% result in spacing patterns of both CpG island density, and to a lesser extent, gene densities. | |
| dc.description | 15 pages (figures included), 5 figures | |
| dc.identifier | https://arxiv.org/abs/q-bio/0411015 | |
| dc.identifier | http://arxiv.org/abs/q-bio/0411015 | |
| dc.identifier | Computational Biology and Chemistry, 28(5-6): 393-399 (2004) | |
| dc.identifier | doi:10.1016/j.compbiolchem.2004.09.011 | |
| dc.identifier.uri | http://salesiana.dossiersoluciones.com/handle/123456789/98127 | |
| dc.subject | Genomics | |
| dc.subject | Quantitative Methods | |
| dc.title | An Unusual 500,000 Bases Long Oscillation of Guanine and Cytosine Content in Human Chromosome 21 | |
| dc.type | text |