A multi-etiology model of systemic degeneration in schizophrenia

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dc.creatorRadulescu, Anca
dc.date2008-08-17
dc.date.accessioned2026-07-07T09:57:06Z
dc.date.available2026-07-07T09:57:06Z
dc.descriptionWe discuss the possibility of multiple underlying etiologies of the condition currently labeled as schizophrenia. We support this hypothesis with a theoretical model of the prefrontal-limbic system. We show how the dynamical behavior of this model depends on an entire set of physiological parameters, representing synaptic strengths, vulnerability to stress-induced cortisol, dopamine regulation and rates of autoantibody production. Malfunction of different such parameters produces similar outward dysregulation of the system, which may readily lead to diagnosis difficulties in a clinician's office. We further place this paradigm within the contexts of pathophysiology and of antipsychotic pharmacology. We finally propose brain profiling as the future quantitative diagnostic toolbox that agrees with a multiple etiologies hypothesis of schizophrenia.
dc.description11 pages, 6 figures, 4 page bibliography
dc.identifierhttps://arxiv.org/abs/0808.2322
dc.identifierhttp://arxiv.org/abs/0808.2322
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/167224
dc.subjectNeurons and Cognition
dc.subjectQuantitative Methods
dc.titleA multi-etiology model of systemic degeneration in schizophrenia
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