Recovery of free energy branches in single molecule experiments

Simple item page
dc.creatorJunier, Ivan
dc.creatorMossa, Alessandro
dc.creatorManosas, Maria
dc.creatorRitort, Felix
dc.date2009-01-25
dc.date.accessioned2026-07-07T12:44:24Z
dc.date.available2026-07-07T12:44:24Z
dc.descriptionWe present a method for determining the free energy of coexisting states from irreversible work measurements. Our approach is based on a fluctuation relation that is valid for dissipative transformations in partially equilibrated systems. To illustrate the validity and usefulness of the approach, we use optical tweezers to determine the free energy branches of the native and unfolded states of a two-state molecule as a function of the pulling control parameter. We determine, within 0.6 kT accuracy, the transition point where the free energies of the native and the unfolded states are equal.
dc.descriptionTo appear in Phys. Rev. Lett. 4 pages + Supp. Mat. (6 pages)
dc.identifierhttps://arxiv.org/abs/0901.3886
dc.identifierhttp://arxiv.org/abs/0901.3886
dc.identifierPhys. Rev. Lett. 102, 070602 (2009)
dc.identifierdoi:10.1103/PhysRevLett.102.070602
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/220759
dc.subjectSoft Condensed Matter
dc.subjectStatistical Mechanics
dc.subjectBiological Physics
dc.titleRecovery of free energy branches in single molecule experiments
dc.typetext

Files

Collections

arXiv