Consistency Principle in Biological Dynamical Systems

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dc.creatorKaneko, Kunihiko
dc.creatorFurusawa, Chikara
dc.date2008-07-11
dc.date.accessioned2026-07-07T09:51:14Z
dc.date.available2026-07-07T09:51:14Z
dc.descriptionWe propose a principle of consistency between different hierarchical levels of biological systems. Given a consistency between molecule replication and cell reproduction, universal statistical laws on cellular chemical abundances are derived and confirmed experimentally. They include a power law distribution of gene expressions, a lognormal distribution of cellular chemical abundances over cells, and embedding of the power law into the network connectivity distribution. Second, given a consistency between genotype and phenotype, a general relationship between phenotype fluctuations by genetic variation and isogenic phenotypic fluctuation by developmental noise is derived. Third, we discuss the chaos mechanism for stem cell differentiation with autonomous regulation, resulting from a consistency between cell reproduction and growth of the cell ensemble.
dc.descriptionAs a proceeding paper for European Confernce on Complex Systems
dc.identifierhttps://arxiv.org/abs/0807.1803
dc.identifierhttp://arxiv.org/abs/0807.1803
dc.identifierTheory Biosci. (2008) 127; 195-204
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/165215
dc.subjectCell Behavior
dc.subjectStatistical Mechanics
dc.subjectAdaptation and Self-Organizing Systems
dc.subjectPopulations and Evolution
dc.subjectSubcellular Processes
dc.titleConsistency Principle in Biological Dynamical Systems
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