Synchronization and clustering of synthetic genetic networks: A role for cis-regulatory modules

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dc.creatorZhang, Jiajun
dc.creatorYuan, Zhanjiang
dc.creatorZhou, Tianshou
dc.date2009-04-03
dc.date.accessioned2026-07-07T13:00:12Z
dc.date.available2026-07-07T13:00:12Z
dc.descriptionThe effect of signal integration through cis-regulatory modules (CRMs) on synchronization and clustering of populations of two-component genetic oscillators coupled by quorum sensing is in detail investigated. We find that the CRMs play an important role in achieving synchronization and clustering. For this, we investigate 6 possible cis-regulatory input functions (CRIFs) with AND, OR, ANDN, ORN, XOR, and EQU types of responses in two possible kinds of cell-to-cell communications: activator-regulated communication (i.e., the autoinducer regulates the activator) and repressor-regulated communication (i.e., the autoinducer regulates the repressor). Both theoretical analysis and numerical simulation show that different CRMs drive fundamentally different cellular patterns, such as complete synchronization, various cluster-balanced states and several cluster-nonbalanced states.
dc.description30 pages, 8 figures
dc.identifierhttps://arxiv.org/abs/0904.0506
dc.identifierhttp://arxiv.org/abs/0904.0506
dc.identifierPhys. Rev. E 79, 041903 (2009)
dc.identifierdoi:10.1103/PhysRevE.79.041903
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/225784
dc.subjectMolecular Networks
dc.subjectQuantitative Methods
dc.titleSynchronization and clustering of synthetic genetic networks: A role for cis-regulatory modules
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