Osmotically Driven Shape Transformations in Axons

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dc.creatorPullarkat, Pramod A.
dc.creatorDommersnes, Paul
dc.creatorFernández, Pablo
dc.creatorJoanny, Jean-François
dc.creatorOtt, Albrecht
dc.creator.
dc.date2006-03-15
dc.date.accessioned2026-07-07T07:07:41Z
dc.date.available2026-07-07T07:07:41Z
dc.descriptionWe report a cylindrical-peristaltic shape transformation in axons exposed to a controlled osmotic perturbation. The peristaltic shape relaxes and the axon recovers its original geometry within minutes. We show that the shape instability depends critically on swelling rate and that volume and membrane area regulation are responsible for the shape relaxation. We propose that volume regulation occurs via leakage of ions driven by elastic pressure, and analyse the peristaltic shape dynamics taking into account the internal structure of the axon. The results obtained provide a framework for understanding peristaltic shape dynamics in nerve fibers occurring in vivo.
dc.description4 pages, 4 figures. Accepted for publication in Physical Review Letters
dc.identifierhttps://arxiv.org/abs/physics/0603122
dc.identifierhttp://arxiv.org/abs/physics/0603122
dc.identifierPhys. Rev. Lett. 96, 048104 (2006)
dc.identifierdoi:10.1103/PhysRevLett.96.048104
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/110483
dc.subjectBiological Physics
dc.subjectFluid Dynamics
dc.titleOsmotically Driven Shape Transformations in Axons
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