Equilibrium study of Protein/DNA Complexes from Crystal Structure Data

Simple item page
dc.creatorSamanta, Sudipta
dc.creatorChakrabarti, J.
dc.creatorBhattacharyya, Dhananjay
dc.date2006-07-14
dc.date.accessioned2026-07-07T07:22:41Z
dc.date.available2026-07-07T07:22:41Z
dc.descriptionFrom the crystal structure data and using the concept of equilbrium statistical mechanics we show how to calculate the thermodynamics of protein/DNA complexes. We apply the method to the TATA-box binding protein (TBP)/TATA sequence complex. We have estimated the change in free energy and entropy for each of the base pair (bp). The local rigidity of the DNA is estimated from the curvature of the free energy. We also estimate the free energy gain of the protein due to bond formation with a particular bp. We thus figure out the bps responsible for specific binding.
dc.description4 pages, 3 figures and 1 table
dc.identifierhttps://arxiv.org/abs/physics/0607143
dc.identifierhttp://arxiv.org/abs/physics/0607143
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/115745
dc.subjectBiological Physics
dc.titleEquilibrium study of Protein/DNA Complexes from Crystal Structure Data
dc.typetext

Files

Collections

arXiv