DNA looping in gene regulation: from the assembly of macromolecular complexes to the control of transcriptional noise

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dc.creatorVilar, Jose M. G.
dc.creatorSaiz, Leonor
dc.date2005-02-28
dc.date.accessioned2026-07-07T06:20:11Z
dc.date.available2026-07-07T06:20:11Z
dc.descriptionThe formation of DNA loops by proteins and protein complexes that bind at distal DNA sites plays a central role in many cellular processes, such as transcription, recombination, and replication. Here we review the basic thermodynamic concepts underlying the assembly of macromolecular complexes on looped DNA and the effects that this process has in the properties of gene regulation. Beyond the traditional view of DNA looping as a mechanism to increase the affinity of regulatory molecules for their cognate sites, recent developments indicate that DNA looping can also lead to the suppression of cell-to-cell variability, the control of transcriptional noise, and the activation of cooperative interactions on demand.
dc.descriptionTo appear in Current Opinion in Genetics & Development
dc.identifierhttps://arxiv.org/abs/q-bio/0502044
dc.identifierhttp://arxiv.org/abs/q-bio/0502044
dc.identifierCurrent Opinion in Genetics & Development, 15, 136-144 (2005)
dc.identifierdoi:10.1016/j.gde.2005.02.005
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/95260
dc.subjectMolecular Networks
dc.subjectSoft Condensed Matter
dc.subjectBiological Physics
dc.subjectBiomolecules
dc.subjectQuantitative Methods
dc.titleDNA looping in gene regulation: from the assembly of macromolecular complexes to the control of transcriptional noise
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