Aging and Immortality in a Cell Proliferation Model

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dc.creatorAntal, T.
dc.creatorBlagoev, K. B.
dc.creatorTrugman, S. A.
dc.creatorRedner, S.
dc.date2006-09-26
dc.date2008-04-23
dc.date.accessioned2026-07-07T09:34:05Z
dc.date.available2026-07-07T09:34:05Z
dc.descriptionWe investigate a model of cell division in which the length of telomeres within the cell regulate their proliferative potential. At each cell division the ends of linear chromosomes change and a cell becomes senescent when one or more of its telomeres become shorter than a critical length. In addition to this systematic shortening, exchange of telomere DNA between the two daughter cells can occur at each cell division. We map this telomere dynamics onto a biased branching diffusion process with an absorbing boundary condition whenever any telomere reaches the critical length. As the relative effects of telomere shortening and cell division are varied, there is a phase transition between finite lifetime and infinite proliferation of the cell population. Using simple first-passage ideas, we quantify the nature of this transition.
dc.description6 pages, 1 figure, 2-column revtex4 format; version 2: final published form; contains various improvements in response to referee comments
dc.identifierhttps://arxiv.org/abs/q-bio/0609040
dc.identifierhttp://arxiv.org/abs/q-bio/0609040
dc.identifierJournal of Theoretical Biology 248, 411-417 (2007)
dc.identifierdoi:10.1016/j.jtbi.2007.06.009
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/159363
dc.subjectCell Behavior
dc.subjectStatistical Mechanics
dc.subjectBiological Physics
dc.titleAging and Immortality in a Cell Proliferation Model
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