Kinetic Accessibility of Buried DNA Sites in Nucleosomes

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dc.creatorMobius, Wolfram
dc.creatorNeher, Richard A.
dc.creatorGerland, Ulrich
dc.date2006-05-11
dc.date2007-08-21
dc.date.accessioned2026-07-07T08:24:32Z
dc.date.available2026-07-07T08:24:32Z
dc.descriptionUsing a theoretical model for spontaneous partial DNA unwrapping from histones, we study the transient exposure of protein-binding DNA sites within nucleosomes. We focus on the functional dependence of the rates for site exposure and reburial on the site position, which is measurable experimentally and pertinent to gene regulation. We find the dependence to be roughly described by a random walker model. Close inspection reveals a surprising physical effect of flexibility-assisted barrier crossing, which we characterize within a toy model, the "semiflexible Brownian rotor."
dc.descriptionfinal version as published in Phys. Rev. Lett
dc.identifierhttps://arxiv.org/abs/q-bio/0605017
dc.identifierhttp://arxiv.org/abs/q-bio/0605017
dc.identifierPhys. Rev. Lett. 97, 208102 (2006)
dc.identifierdoi:10.1103/PhysRevLett.97.208102
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/136369
dc.subjectSubcellular Processes
dc.titleKinetic Accessibility of Buried DNA Sites in Nucleosomes
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