Sequence dependence of DNA translocation through a nanopore

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dc.creatorLuo, Kaifu
dc.creatorAla-Nissila, Tapio
dc.creatorYing, See-Chen
dc.creatorBhattacharya, Aniket
dc.date2007-11-21
dc.date2007-12-01
dc.date.accessioned2026-07-07T09:18:23Z
dc.date.available2026-07-07T09:18:23Z
dc.descriptionWe investigate the dynamics of DNA translocation through a nanopore using 2D Langevin dynamics simulations, focusing on the dependence of the translocation dynamics on the details of DNA sequences. The DNA molecules studied in this work are built from two types of bases $A$ and $C$, which has been shown previously to have different interactions with the pore. We study DNA with repeating blocks $A_nC_n$ for various values of $n$, and find that the translocation time depends strongly on the {\em block length} $2n$ as well as on the {\em orientation} of which base entering the pore first. Thus, we demonstrate that the measurement of translocation dynamics of DNA through nanopore can yield detailed information about its structure. We have also found that the periodicity of the block sequences are contained in the periodicity of the residence time of the individual nucleotides inside the pore.
dc.description4 pages, 4 figures, minor changes
dc.identifierhttps://arxiv.org/abs/0711.3246
dc.identifierhttp://arxiv.org/abs/0711.3246
dc.identifierPhys. Rev. Lett. 100, 058101 (2008)
dc.identifierdoi:10.1103/PhysRevLett.100.058101
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/154008
dc.subjectSoft Condensed Matter
dc.subjectStatistical Mechanics
dc.titleSequence dependence of DNA translocation through a nanopore
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