Mean first passage times for bond formation for a Brownian particle in linear shear flow above a wall

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dc.creatorKorn, C.
dc.creatorSchwarz, U. S.
dc.date2006-10-11
dc.date2007-07-16
dc.date.accessioned2026-07-07T08:17:39Z
dc.date.available2026-07-07T08:17:39Z
dc.descriptionMotivated by cell adhesion in hydrodynamic flow, here we study bond formation between a spherical Brownian particle in linear shear flow carrying receptors for ligands covering the boundary wall. We derive the appropriate Langevin equation which includes multiplicative noise due to position-dependent mobility functions resulting from the Stokes equation. We present a numerical scheme which allows to simulate it with high accuracy for all model parameters, including shear rate and three parameters describing receptor geometry (distance, size and height of the receptor patches). In the case of homogeneous coating, the mean first passage time problem can be solved exactly. In the case of position-resolved receptor-ligand binding, we identify different scaling regimes and discuss their biological relevance.
dc.descriptionfinal version after minor revisions
dc.identifierhttps://arxiv.org/abs/cond-mat/0610302
dc.identifierhttp://arxiv.org/abs/cond-mat/0610302
dc.identifierJ. Chem. Phys. 126, 095103 (2007)
dc.identifierdoi:10.1063/1.2464080
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/134166
dc.subjectSoft Condensed Matter
dc.subjectCell Behavior
dc.titleMean first passage times for bond formation for a Brownian particle in linear shear flow above a wall
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