Collecting single molecules with conventional optical tweezers

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dc.creatorSinger, Wolfgang
dc.creatorNieminen, Timo A.
dc.creatorHeckenberg, Norman R.
dc.creatorRubinsztein-Dunlop, Halina
dc.date2007-02-06
dc.date.accessioned2026-07-07T07:45:08Z
dc.date.available2026-07-07T07:45:08Z
dc.descriptionThe size of particles which can be trapped in optical tweezers ranges from tens of nanometres to tens of micrometres. This size regime also includes large single molecules. Here we present experiments demonstrating that optical tweezers can be used to collect polyethylene oxide (PEO) molecules suspended in water. The molecules that accumulate in the focal volume do not aggregate and therefore represent a region of increased molecule concentration, which can be controlled by the trapping potential. We also present a model which relates the change in concentration to the trapping potential. Since many protein molecules have molecular weights for which this method is applicable the effect may be useful in assisting nucleation of protein crystals.
dc.description5 pages, 4 figures
dc.identifierhttps://arxiv.org/abs/physics/0702044
dc.identifierhttp://arxiv.org/abs/physics/0702044
dc.identifierPhysical Review E 75(1), 011916 (2007)
dc.identifierdoi:10.1103/PhysRevE.75.011916
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/123438
dc.subjectOptics
dc.subjectClassical Physics
dc.titleCollecting single molecules with conventional optical tweezers
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