Post-transcriptional Regulation Drives Temporal Compartmentalization of the Yeast Metabolic Cycle

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dc.creatorPalumbo, Maria Concetta
dc.creatorFarina, Lorenzo
dc.creatorDe Santis, Alberto
dc.creatorGiuliani, Alessandro
dc.creatorColosimo, Alfredo
dc.creatorMorelli, Giorgio
dc.creatorRuberti, Ida
dc.date2007-07-25
dc.date.accessioned2026-07-07T08:20:12Z
dc.date.available2026-07-07T08:20:12Z
dc.descriptionThe maintainance of a stable periodicity during the yeast metabolic cycle involving approximately half of the genome requires a very strict and efficient control of gene expression. For this reason, the metabolic cycle is a very good candidate for testing the role of a class of post-transcriptional regulators, the so called PUF-family, whose genome-wide mRNA binding specificity was recently experimentally assessed. Here we show that an integrated computational analysis of gene expression time series during the metabolic cycle and the mRNA binding specificity of PUF-family proteins allow for a clear demonstration of the very specific role exerted by selective post-transcriptional mRNA degradation in yeast metabolic cycle global regulation.
dc.description13 pages, 4 figures, 1 table
dc.identifierhttps://arxiv.org/abs/0707.3716
dc.identifierhttp://arxiv.org/abs/0707.3716
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/135005
dc.subjectCell Behavior
dc.subjectBiomolecules
dc.titlePost-transcriptional Regulation Drives Temporal Compartmentalization of the Yeast Metabolic Cycle
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