Transport by molecular motors in the presence of static defects

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dc.creatorChai, Yan
dc.creatorLipowsky, Reinhard
dc.creatorKlumpp, Stefan
dc.date2009-05-07
dc.date.accessioned2026-07-07T13:12:35Z
dc.date.available2026-07-07T13:12:35Z
dc.descriptionThe transport by molecular motors along cytoskeletal filaments is studied theoretically in the presence of static defects. The movements of single motors are described as biased random walks along the filament as well as binding to and unbinding from the filament. Three basic types of defects are distinguished, which differ from normal filament sites only in one of the motors' transition probabilities. Both stepping defects with a reduced probability for forward steps and unbinding defects with an increased probability for motor unbinding strongly reduce the velocities and the run lengths of the motors with increasing defect density. For transport by single motors, binding defects with a reduced probability for motor binding have a relatively small effect on the transport properties. For cargo transport by motors teams, binding defects also change the effective unbinding rate of the cargo particles and are expected to have a stronger effect.
dc.description20 pages, latex, 7 figures, 1 table
dc.identifierhttps://arxiv.org/abs/0905.0965
dc.identifierhttp://arxiv.org/abs/0905.0965
dc.identifierJ. Stat. Phys. 135, 241-260 (2009)
dc.identifierdoi:10.1007/s10955-009-9715-3
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/229626
dc.subjectBiological Physics
dc.subjectSoft Condensed Matter
dc.subjectSubcellular Processes
dc.titleTransport by molecular motors in the presence of static defects
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