Insertion of a magnesium(II)-octacarboranyl(hexylsulfanyl) porphyrazine into liposomes: a physico-chemical study

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The synthesis, characterization and liposome insertion of a novel magnesium(II) carboranyl-porphyrazine, i.e. [2,3,7,8,12,13,17,18-octakis- (1,2-dicarba-closo-dodecaboranyl)-hexylthio-5,10,15,20- porphyrazine]magnesium(II) complex, MgHECSPz, is described. MgHECSPz was designed to improve the potentiality in multiple approach anticancer therapy. Liposomal formulations with different surface charge were prepared as delivering agents. The obtained loaded vectors were characterized by DLS, SAXS, SANS and ζpotential measurements in order to define the overall properties and structural details of loaded liposomes.

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Soft Condensed Matter, Biological Physics

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http://salesiana.dossiersoluciones.com/handle/123456789/137586

Consulte el texto completo en el siguiente enlace:

https://arxiv.org/abs/0709.1012
 http://arxiv.org/abs/0709.1012

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arXiv