A Study of Sequence Distribution of a Painted Globule as a Model for Proteins with Good Folding Properties
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In this paper we present a method to study the folding structure of a simple model consisting of two kinds of monomers, hydrophobic and hydrophilic. This method has three main steps: an efficient simulation method to bring an open sequence of homopolymer to a folded state, the application of a painting method called (regular hull) to the folded globule and the refolding process of the obtained copolymer sequence. This study allows us to suggest a theoretical function of disorder distribution for copolymer sequences that give rise to a compacted and well micro-phase separated globule.
11 pages incl. 6 PS figures. Paper presented at the International Conference on Morphology and Kinetics of Phase Separating Complex Fluids, Messina, Italy, June 1997
11 pages incl. 6 PS figures. Paper presented at the International Conference on Morphology and Kinetics of Phase Separating Complex Fluids, Messina, Italy, June 1997