Translocation of a Single Stranded DNA Through a Conformationally Changing Nanopore

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dc.creatorFlomenbom, O.
dc.creatorKlafter, J.
dc.date2003-08-11
dc.date2004-02-12
dc.date.accessioned2026-07-07T02:52:52Z
dc.date.available2026-07-07T02:52:52Z
dc.descriptionWe investigate the translocation of a single stranded DNA through a pore which fluctuates between two conformations, using coupled master equations. The probability density function of the first passage times (FPT) of the translocation process is calculated, displaying a triple, double or mono peaked behavior, depending on the interconversion rates between the conformations, the applied electric field, and the initial conditions. The cumulative probability function of the FPT, in a field-free environment, is shown to have two regimes, characterized by fast and slow timescales. An analytical expression for the mean first passage time of the translocation process is derived, and provides, in addition to the interconversion rates, an extensive characterization of the translocation process. Relationships to experimental observations are discussed.
dc.description8 pages, 5 figures, Biophys. J., in press
dc.identifierhttps://arxiv.org/abs/cond-mat/0308199
dc.identifierhttp://arxiv.org/abs/cond-mat/0308199
dc.identifierBiophys. J. 86: 3576-3584 (2004)
dc.identifierdoi:10.1529/biophysj.103.037580
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/22002
dc.subjectStatistical Mechanics
dc.subjectSoft Condensed Matter
dc.subjectSubcellular Processes
dc.titleTranslocation of a Single Stranded DNA Through a Conformationally Changing Nanopore
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