Optimal homogenization of perfusion flows in microfluidic bio-reactors; a numerical study

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dc.creatorOkkels, Fridolin
dc.creatorDufva, Martin
dc.creatorBruus, Henrik
dc.date2009-05-19
dc.date.accessioned2026-07-07T13:16:27Z
dc.date.available2026-07-07T13:16:27Z
dc.descriptionTo ensure homogeneous conditions within the complete area of perfused microfluidic bio-reactors, we develop a general design of a continuously feed bio-reactor with uniform perfusion flow. This is achieved by introducing a specific type of perfusion inlet to the reaction area. The geometry of these inlets are found using the methods of topology optimization and shape optimization. The results are compared with two different analytic models, from which a general parametric description of the design is obtained and tested numerically. Such a parametric description will generally be beneficial for the design of a broad range of microfluidic bioreactors used for e.g. cell culturing and analysis, and in feeding bio-arrays.
dc.description15 pages, 8 figures
dc.identifierhttps://arxiv.org/abs/0905.3064
dc.identifierhttp://arxiv.org/abs/0905.3064
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/230795
dc.subjectFluid Dynamics
dc.subjectComputational Physics
dc.titleOptimal homogenization of perfusion flows in microfluidic bio-reactors; a numerical study
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