Theoretical models for single-molecule DNA and RNA experiments: from elasticity to unzipping

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dc.creatorCocco, S.
dc.creatorMarko, J. F.
dc.creatorMonasson, R.
dc.date2002-06-13
dc.date.accessioned2026-07-07T02:45:50Z
dc.date.available2026-07-07T02:45:50Z
dc.descriptionWe review statistical-mechanical theories of single-molecule micromanipulation experiments on nucleic acids. First, models for describing polymer elasticity are introduced. We then review how these models are used to interpret single-molecule force-extension experiments on single-stranded and double-stranded DNA. Depending on the force and the molecules used, both smooth elastic behaviors and abrupt structural transitions are observed. Third, we show how combining the elasticity of two single nucleic acid strands with a description of the base-pairing interactions between them explains much of the phenomenology and kinetics of RNA and DNA `unzipping' experiments.
dc.descriptionto appear in CRAS, special issue dedicated to Single Molecule Experiments
dc.identifierhttps://arxiv.org/abs/cond-mat/0206238
dc.identifierhttp://arxiv.org/abs/cond-mat/0206238
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/19447
dc.subjectSoft Condensed Matter
dc.subjectQuantitative Biology
dc.titleTheoretical models for single-molecule DNA and RNA experiments: from elasticity to unzipping
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