Robustness and fragility of Boolean models for genetic regulatory networks

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dc.creatorChaves, Madalena
dc.creatorAlbert, Reka
dc.creatorSontag, Eduardo D.
dc.date2005-01-27
dc.date.accessioned2026-07-07T06:22:08Z
dc.date.available2026-07-07T06:22:08Z
dc.descriptionInteractions between genes and gene products give rise to complex circuits that enable cells to process information and respond to external signals. Theoretical studies often describe these interactions using continuous, stochastic, or logical approaches. We propose a new modeling framework for gene regulatory networks, that combines the intuitive appeal of a qualitative description of gene states with a high flexibility in incorporating stochasticity in the duration of cellular processes. We apply our methods to the regulatory network of the segment polarity genes, thus gaining novel insights into the development of gene expression patterns. For example, we show that very short synthesis and decay times can perturb the wild type pattern. On the other hand, separation of timescales between pre- and posttranslational processes and a minimal prepattern ensure convergence to the wild type expression pattern regardless of fluctuations.
dc.description29 pages, 5 figures, accepted to the Journal of Theoretical Biology
dc.identifierhttps://arxiv.org/abs/q-bio/0501037
dc.identifierhttp://arxiv.org/abs/q-bio/0501037
dc.identifierJournal of Theoretical Biology 235, 431-449 (2005)
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/95820
dc.subjectMolecular Networks
dc.titleRobustness and fragility of Boolean models for genetic regulatory networks
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