How does the chromatin fiber deal with topological constraints?

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dc.creatorBarbi, Maria
dc.creatorMozziconacci, Julien
dc.creatorVictor, Jean-Marc
dc.date2004-04-26
dc.date2004-05-12
dc.date.accessioned2026-07-07T06:23:56Z
dc.date.available2026-07-07T06:23:56Z
dc.descriptionIn the nuclei of eukaryotic cells, DNA is packaged through several levels of compaction in an orderly retrievable way that enables the correct regulation of gene expression. The functional dynamics of this assembly involves the unwinding of the so-called 30 nm chromatin fiber and accordingly imposes strong topological constraints. We present a general method for computing both the twist and the writhe of any winding pattern. An explicit derivation is implemented for the chromatin fiber which provides the linking number of DNA in eukaryotic chromosomes. We show that there exists one and only one unwinding path which satisfies both topological and mechanical constraints that DNA has to deal with during condensation/decondensation processes.
dc.descriptionPresented in Nature "News and views in brief" Vol. 429 (13 May 2004). Movies available at http://www.lptl.jussieu.fr/recherche/operationE_fichiers/Page_figurePRL.html
dc.identifierhttps://arxiv.org/abs/q-bio/0404037
dc.identifierhttp://arxiv.org/abs/q-bio/0404037
dc.identifierPhysical Review E, 71, 031910 (2005)
dc.identifierdoi:10.1103/PhysRevE.71.031910
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/96382
dc.subjectSubcellular Processes
dc.subjectSoft Condensed Matter
dc.subjectBiological Physics
dc.titleHow does the chromatin fiber deal with topological constraints?
dc.typetext

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