Dynamical hysteresis in multisite protein modification

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dc.creatorMilotti, Edoardo
dc.creatorDel Fabbro, Alessio
dc.creatorPellegrina, Chiara Dalla
dc.creatorChignola, Roberto
dc.date2007-02-12
dc.date.accessioned2026-07-07T07:49:41Z
dc.date.available2026-07-07T07:49:41Z
dc.descriptionMultisite protein modification is a ubiquitous mechanism utilized by cells to control protein functions. We have recently proposed a dynamical description of multisite protein modification which embodies all the essential features of the process (E. Milotti, A. Del Fabbro, C. Dalla Pellegrina, and R. Chignola, Physica A, in press), and we have used this model to analyze the stability and the time-scales of this mechanism. The same model can be used to understand how the system responds to stimuli: here we show that it displays frequency-dependent dynamical hysteresis. This behavior closely parallels -- with the due differences -- what is observed in magnetic systems. By selecting model parameters that span the known biological ranges, we find that the frequency-dependent features cover the band of the observed oscillations of molecular intracellular signals, and this suggests that this mechanism may have an important role in cellular information processing.
dc.description5 figures
dc.identifierhttps://arxiv.org/abs/physics/0702094
dc.identifierhttp://arxiv.org/abs/physics/0702094
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/124946
dc.subjectBiological Physics
dc.subjectMolecular Networks
dc.titleDynamical hysteresis in multisite protein modification
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