Di-nucleotide Entropy as a Measure of Genomic Sequence Functionality
| dc.creator | Parkhomchuk, Dmitri | |
| dc.date | 2006-11-17 | |
| dc.date | 2006-12-19 | |
| dc.date.accessioned | 2026-07-07T07:36:08Z | |
| dc.date.available | 2026-07-07T07:36:08Z | |
| dc.description | Considering vast amounts of genomic sequences of mostly unknown functionality, in-silico prediction of functional regions is an important enterprise. Many genomic browsers employ GC content, which was observed to be elevated in gene-rich functional regions. This report shows that the entropy of di- and tri-nucleotides distributions provides a superior measure of genomic sequence functionality, and proposes an explanation on why the GC content must be elevated (closer to 50%) in functional regions. Regions with high entropy strongly co-localize with exons and provide genome-wide evidences of purifying selection acting on non-coding regions, such as decreased SNPs density. The observations suggest that functional non-coding regions are optimised for mutation load in a way, that transition mutations have less impact on functionality than transversions, leading to the decrease in transversions to transitions ratio in functional regions. | |
| dc.description | 10 pages, 7 figures, grammatical revision | |
| dc.identifier | https://arxiv.org/abs/q-bio/0611059 | |
| dc.identifier | http://arxiv.org/abs/q-bio/0611059 | |
| dc.identifier.uri | http://salesiana.dossiersoluciones.com/handle/123456789/120322 | |
| dc.subject | Genomics | |
| dc.title | Di-nucleotide Entropy as a Measure of Genomic Sequence Functionality | |
| dc.type | text |