Single DNA conformations and biological function

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dc.creatorMetzler, Ralf
dc.creatorAmbjoernsson, Tobias
dc.creatorHanke, Andreas
dc.creatorZhang, Yongli
dc.creatorLevene, Stephen
dc.date2006-09-15
dc.date2006-11-14
dc.date.accessioned2026-07-07T07:26:08Z
dc.date.available2026-07-07T07:26:08Z
dc.descriptionFrom a nanoscience perspective, cellular processes and their reduced in vitro imitations provide extraordinary examples for highly robust few or single molecule reaction pathways. A prime example are biochemical reactions involving DNA molecules, and the coupling of these reactions to the physical conformations of DNA. In this review, we summarise recent results on the following phenomena: We investigate the biophysical properties of DNA-looping and the equilibrium configurations of DNA-knots, whose relevance to biological processes are increasingly appreciated. We discuss how random DNA-looping may be related to the efficiency of the target search process of proteins for their specific binding site on the DNA molecule. And we dwell on the spontaneous formation of intermittent DNA nanobubbles and their importance for biological processes, such as transcription initiation. The physical properties of DNA may indeed turn out to be particularly suitable for the use of DNA in nanosensing applications.
dc.description53 pages, 45 figures. Slightly revised version of a review article, that is going to appear in the J. Comput. Theoret. Nanoscience; some typos corrected
dc.identifierhttps://arxiv.org/abs/physics/0609139
dc.identifierhttp://arxiv.org/abs/physics/0609139
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/116970
dc.subjectBiological Physics
dc.subjectSoft Condensed Matter
dc.subjectBiomolecules
dc.titleSingle DNA conformations and biological function
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