In vivo evidence of alternative loop geometries in DNA-protein complexes

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dc.creatorSaiz, Leonor
dc.creatorVilar, Jose M. G.
dc.date2006-02-10
dc.date.accessioned2026-07-07T07:04:12Z
dc.date.available2026-07-07T07:04:12Z
dc.descriptionThe in vivo free energy of looping double-stranded DNA by the lac repressor has a remarkable behavior whose origins are not fully understood. In addition to the intrinsic periodicity of the DNA double helix, the in vivo free energy has an oscillatory component of about half the helical period and oscillates asymmetrically with an amplitude significantly smaller than predicted by current theories. Here, we show that the in vivo behavior is accurately accounted for by the simultaneous presence of two distinct conformations of looped DNA. Our analysis reveals that these two conformations have different optimal free energies and phases and that they behave distinctly in the presence of key architectural proteins.
dc.description3 pages, 2 figures
dc.identifierhttps://arxiv.org/abs/q-bio/0602012
dc.identifierhttp://arxiv.org/abs/q-bio/0602012
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/109271
dc.subjectBiomolecules
dc.subjectSoft Condensed Matter
dc.subjectBiological Physics
dc.titleIn vivo evidence of alternative loop geometries in DNA-protein complexes
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