Modeling multi-cellular systems using sub-cellular elements
| dc.creator | Newman, T. J. | |
| dc.date | 2005-04-20 | |
| dc.date.accessioned | 2026-07-07T05:59:13Z | |
| dc.date.available | 2026-07-07T05:59:13Z | |
| dc.description | We introduce a model for describing the dynamics of large numbers of interacting cells. The fundamental dynamical variables in the model are sub-cellular elements, which interact with each other through phenomenological intra- and inter-cellular potentials. Advantages of the model include i) adaptive cell-shape dynamics, ii) flexible accommodation of additional intra-cellular biology, and iii) the absence of an underlying grid. We present here a detailed description of the model, and use successive mean-field approximations to connect it to more coarse-grained approaches, such as discrete cell-based algorithms and coupled partial differential equations. We also discuss efficient algorithms for encoding the model, and give an example of a simulation of an epithelial sheet. Given the biological flexibility of the model, we propose that it can be used effectively for modeling a range of multi-cellular processes, such as tumor dynamics and embryogenesis. | |
| dc.description | 20 pages, 4 figures | |
| dc.identifier | https://arxiv.org/abs/q-bio/0504028 | |
| dc.identifier | http://arxiv.org/abs/q-bio/0504028 | |
| dc.identifier.uri | http://salesiana.dossiersoluciones.com/handle/123456789/88601 | |
| dc.subject | Quantitative Methods | |
| dc.title | Modeling multi-cellular systems using sub-cellular elements | |
| dc.type | text |