Characterizing neuromorphologic alterations with additive shape functionals

Simple item page
dc.creatorBarbosa, M. S.
dc.creatorCosta, L. da F.
dc.creatorBernardes, E. S.
dc.creatorRamakers, G.
dc.creatorvan Pelt, J.
dc.date2004-08-09
dc.date.accessioned2026-07-07T05:58:35Z
dc.date.available2026-07-07T05:58:35Z
dc.descriptionThe complexity of a neuronal cell shape is known to be related to its function. Specifically, among other indicators, a decreased complexity in the dendritic trees of cortical pyramidal neurons has been associated with mental retardation. In this paper we develop a procedure to address the characterization of morphological changes induced in cultured neurons by over-expressing a gene involved in mental retardation. Measures associated with the multiscale connectivity, an additive image functional, are found to give a reasonable separation criterion between two categories of cells. One category consists of a control group and two transfected groups of neurons, and the other, a class of cat ganglionary cells. The reported framework also identified a trend towards lower complexity in one of the transfected groups. Such results establish the suggested measures as an effective descriptors of cell shape.
dc.identifierhttps://arxiv.org/abs/q-bio/0408004
dc.identifierhttp://arxiv.org/abs/q-bio/0408004
dc.identifierEur. Phys. J. B 37, 109 115 (2004)
dc.identifierdoi:10.1140/epjb/e2004-00035-y
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/88409
dc.subjectQuantitative Methods
dc.subjectStatistical Mechanics
dc.titleCharacterizing neuromorphologic alterations with additive shape functionals
dc.typetext

Files

Collections

arXiv