The role of M cells and the long QT syndrome in cardiac arrhythmias: simulation studies of reentrant excitations using a detailed electrophysiological model
| dc.creator | Henry, Hervé | |
| dc.creator | Rappel, Wouter-Jan | |
| dc.date | 2004-07-19 | |
| dc.date.accessioned | 2026-07-07T05:58:34Z | |
| dc.date.available | 2026-07-07T05:58:34Z | |
| dc.description | In this numerical study, we investigate the role of intrinsic heterogeneities of cardiac tissue due to M cells in the generation and maintenance of reentrant excitations using the detailed Luo-Rudy dynamic model. This model has been extended to include a description of the long QT 3 syndrome, and is studied in both one dimension, corresponding to a cable traversing the ventricular wall, and two dimensions, representing a transmural slice. We focus on two possible mechanisms for the generation of reentrant events. We first investigate if early-after-depolarizations occurring in M cells can initiate reentry. We find that, even for large values of the long QT strength, the electrotonic coupling between neighboring cells prevents early-after-depolarizations from creating a reentry. We then study whether M cell domains, with their slow repolarization, can function as wave blocks for premature stimuli. We find that the inclusion of an M cell domain can result in some cases in reentrant excitations and we determine the lifetime of the reentry as a function of the size and geometry of the domain and of the strength of the long QT syndrome. | |
| dc.identifier | https://arxiv.org/abs/q-bio/0407027 | |
| dc.identifier | http://arxiv.org/abs/q-bio/0407027 | |
| dc.identifier | Chaos Vol 14 pages 172-182 (2004) | |
| dc.identifier | doi:10.1063/1.1636272 | |
| dc.identifier.uri | http://salesiana.dossiersoluciones.com/handle/123456789/88402 | |
| dc.subject | Tissues and Organs | |
| dc.subject | Other Condensed Matter | |
| dc.subject | Pattern Formation and Solitons | |
| dc.subject | Other Quantitative Biology | |
| dc.title | The role of M cells and the long QT syndrome in cardiac arrhythmias: simulation studies of reentrant excitations using a detailed electrophysiological model | |
| dc.type | text |