Segmentation of DNA sequences into twostate regions and melting fork regions

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dc.creatorTøstesen, Eivind
dc.creatorSandve, Geir Kjetil
dc.creatorLiu, Fang
dc.creatorHovig, Eivind
dc.date2008-06-12
dc.date2008-11-28
dc.date.accessioned2026-07-07T12:13:14Z
dc.date.available2026-07-07T12:13:14Z
dc.descriptionThe accurate prediction and characterization of DNA melting domains by computational tools could facilitate a broad range of biological applications. However, no algorithm for melting domain prediction has been available until now. The main challenges include the difficulty of mathematically mapping a qualitative description of DNA melting domains to quantitative statistical mechanics models, as well as the absence of 'gold standards' and a need for generality. In this paper, we introduce a new approach to identify the twostate regions and melting fork regions along a given DNA sequence. Compared with an ad hoc segmentation used in one of our previous studies, the new algorithm is based on boundary probability profiles, rather than standard melting maps. We demonstrate that a more detailed characterization of the DNA melting domain map can be obtained using our new method, and this approach is independent of the choice of DNA melting model. We expect this work to drive our understanding of DNA melting domains one step further.
dc.description17 pages, 8 figures; new introduction, added refs, minor changes
dc.identifierhttps://arxiv.org/abs/0806.2059
dc.identifierhttp://arxiv.org/abs/0806.2059
dc.identifierJ. Phys.: Condens. Matter 21 (2009) 034109
dc.identifierdoi:10.1088/0953-8984/21/3/034109
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/210779
dc.subjectBiomolecules
dc.subjectGenomics
dc.titleSegmentation of DNA sequences into twostate regions and melting fork regions
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