The thermodynamics of general anesthesia

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dc.creatorHeimburg, Thomas
dc.creatorJackson, Andrew D.
dc.date2006-10-19
dc.date.accessioned2026-07-07T09:30:54Z
dc.date.available2026-07-07T09:30:54Z
dc.descriptionIt is known that the action of general anesthetics is proportional to their partition coefficient in lipid membranes (Meyer-Overton rule). This solubility is, however, directly related to the depression of the temperature of the melting transition found close to body temperature in biomembranes. We propose a thermodynamic extension of the Meyer-Overton rule which is based on free energy changes in the system and thus automatically incorporates the effects of melting point depression. This model provides a quantitative explanation of the pressure reversal of anesthesia. Further, it explains why inflammation and the addition of divalent cations reduce the effectiveness of anesthesia.
dc.description7 pages, 2 figures
dc.identifierhttps://arxiv.org/abs/physics/0610147
dc.identifierhttp://arxiv.org/abs/physics/0610147
dc.identifierBiophys. J. 92 (2007) 3159-3165
dc.identifierdoi:10.1529/biophysj.106.099754
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/158272
dc.subjectBiological Physics
dc.subjectMedical Physics
dc.titleThe thermodynamics of general anesthesia
dc.typetext

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