Three phases in the evolution of the standard genetic code: how translation could get started
| dc.creator | van der Gulik, Peter | |
| dc.date | 2007-11-05 | |
| dc.date.accessioned | 2026-07-07T08:40:46Z | |
| dc.date.available | 2026-07-07T08:40:46Z | |
| dc.description | A primordial genetic code is proposed, having only four codons assigned, GGC meaning glycine, GAC meaning aspartate/glutamate, GCC meaning alanine-like and GUC meaning valine-like. Pathways of ambiguity reduction enlarged the codon repertoire with CUC meaning leucine, AUC meaning isoleucine, ACC meaning threonine-like and GAG meaning glutamate. Introduction of UNN anticodons, in a next episode of code evolution in which nonsense elimination was the leading theme, introduced a family box structure superposed on the original mirror structure. Finally, growth rate was the leading theme during the remaining repertoire expansion, explaining the ordered phylogenetic pattern of aminoacyl-tRNA synthetases. The special role of natural aptamers in the process is high-lighted, and the error robustness characteristics of the code are shown to have evolved by way of a stepwise, restricted enlargement of the tRNA repertoire, instead of by an exhaustive selection process testing myriads of codes. | |
| dc.identifier | https://arxiv.org/abs/0711.0700 | |
| dc.identifier | http://arxiv.org/abs/0711.0700 | |
| dc.identifier.uri | http://salesiana.dossiersoluciones.com/handle/123456789/141466 | |
| dc.subject | Populations and Evolution | |
| dc.title | Three phases in the evolution of the standard genetic code: how translation could get started | |
| dc.type | text |