Model evaluation for glycolytic oscillations in yeast biotransformations of xenobiotics

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dc.creatorBrusch, Lutz
dc.creatorCuniberti, Gianaurelio
dc.creatorBertau, Martin
dc.date2004-04-26
dc.date.accessioned2026-07-07T05:58:24Z
dc.date.available2026-07-07T05:58:24Z
dc.descriptionAnaerobic glycolysis in yeast perturbed by the reduction of xenobiotic ketones is studied numerically in two models which possess the same topology but different levels of complexity. By comparing both models' predictions for concentrations and fluxes as well as steady or oscillatory temporal behavior we answer the question what phenomena require what kind of minimum model abstraction. While mean concentrations and fluxes are predicted in agreement by both models we observe different domains of oscillatory behavior in parameter space. Generic properties of the glycolytic response to ketones are discussed.
dc.identifierhttps://arxiv.org/abs/q-bio/0404036
dc.identifierhttp://arxiv.org/abs/q-bio/0404036
dc.identifierBiophysical Chemistry 109, 413-426 (2004)
dc.identifierdoi:10.1016/j.bpc.2003.12.004
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/88342
dc.subjectMolecular Networks
dc.subjectQuantitative Methods
dc.titleModel evaluation for glycolytic oscillations in yeast biotransformations of xenobiotics
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