Neuronal synchrony during anaesthesia - A thalamocortical model

Sheeba, Jane H.; Stefanovska, Aneta; McClintock, Peter V. E.

Neuronal synchrony during anaesthesia - A thalamocortical model

Authors

Sheeba, Jane H.

Stefanovska, Aneta

McClintock, Peter V. E.

Description

There is growing evidence in favour of the temporal-coding hypothesis that temporal correlation of neuronal discharges may serve to bind distributed neuronal activity into unique representations and, in particular, that $θ$ (3.5-7.5 Hz) and $δ$ ($0.5<$3.5 Hz) oscillations facilitate information coding. The $θ$ and $δ$ rhythms are shown to be involved in various sleep stages, and during anæsthesia, and they undergo changes with the depth of anæsthesia. We introduce a thalamocortical model of interacting neuronal ensembles to describe phase relationships between $θ$ and $δ$ oscillations, especially during deep and light anæsthesia. Asymmetric and long range interactions among the thalamocortical neuronal oscillators are taken into account. The model results are compared with the experimental observations of Musizza et al. {\it J. Physiol. (London)} 2007 580:315-326. The $δ$ and $θ$ activities are found to be separately generated and are governed by the thalamus and cortex respectively. Changes in the degree of intra--ensemble and inter--ensemble synchrony imply that the neuronal ensembles inhibit information coding during deep anæsthesia and facilitate it during light anæsthesia.
18 pages, 3 figures