Evolutionary conservation of the folding nucleus

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dc.creatorMirny, Leonid
dc.creatorShakhnovich, Eugene
dc.date2000-12-01
dc.date.accessioned2026-07-07T05:45:07Z
dc.date.available2026-07-07T05:45:07Z
dc.descriptionIn this Communication we present statistical analysis of conservation profiles in families of homologous sequences for nine proteins whose folding nucleus was determined by protein engineering methods. We show that in all but one protein (AcP) folding nucleus residues are significantly more conserved than the rest of the protein. Two aspects of our study are especially important: 1) grouping of amino acids into classes according to their physical-chemical properties and 2) proper normalization of amino acid probabilities that reflects the fact that evolutionary pressure to conserve some amino acid types may itself affect concentration of various amino acid types in protein families. Neglect of any of those two factors may make physical and biological ``signals'' from conservation profiles disappear.
dc.descriptionsubmitted to Journal of Molecular Biology
dc.identifierhttps://arxiv.org/abs/physics/0012003
dc.identifierhttp://arxiv.org/abs/physics/0012003
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/83893
dc.subjectBiological Physics
dc.subjectStatistical Mechanics
dc.subjectChemical Physics
dc.subjectQuantitative Biology
dc.titleEvolutionary conservation of the folding nucleus
dc.typetext

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