Calculating event-triggered average synaptic conductances from the membrane potential

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dc.creatorPospischil, Martin
dc.creatorPiwkowska, Zuzanna
dc.creatorRudolph, Michelle
dc.creatorBal, Thierry
dc.creatorDestexhe, Alain
dc.date2006-09-20
dc.date2007-03-01
dc.date.accessioned2026-07-07T07:49:25Z
dc.date.available2026-07-07T07:49:25Z
dc.descriptionThe optimal patterns of synaptic conductances for spike generation in central neurons is a subject of considerable interest. Ideally, such conductance time courses should be extracted from membrane potential (Vm) activity, but this is difficult because the nonlinear contribution of conductances to the Vm renders their estimation from the membrane equation extremely sensitive. We outline here a solution to this problem based on a discretization of the time axis. This procedure can extract the time course of excitatory and inhibitory conductances solely from the analysis of Vm activity. We test this method by calculating spike-triggered averages of synaptic conductances using numerical simulations of the integrate-and-fire model subject to colored conductance noise. The procedure was also tested successfully in biological cortical neurons using conductance noise injected with dynamic-clamp. This method should allow the extraction of synaptic conductances from Vm recordings in vivo.
dc.description10 pages, 8 figures; final version published in the Journal of Neurophysiology
dc.identifierhttps://arxiv.org/abs/q-bio/0609030
dc.identifierhttp://arxiv.org/abs/q-bio/0609030
dc.identifierJournal of Neurophysiology, 97: 2544--2552 (2007)
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/124843
dc.subjectNeurons and Cognition
dc.titleCalculating event-triggered average synaptic conductances from the membrane potential
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