Interaction between directional epistasis and average mutational effects

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dc.creatorWilke, Claus O.
dc.creatorAdami, Christoph
dc.date2000-07-17
dc.date2001-06-28
dc.date.accessioned2026-07-07T05:44:19Z
dc.date.available2026-07-07T05:44:19Z
dc.descriptionWe investigate the relationship between the average fitness decay due to single mutations and the strength of epistatic interactions in genetic sequences. We observe that epistatic interactions between mutations are correlated to the average fitness decay, both in RNA secondary structure prediction as well as in digital organisms replicating in silico. This correlation implies that during adaptation, epistasis and average mutational effect cannot be optimized independently. In experiments with RNA sequences evolving on a neutral network, the selective pressure to decrease the mutational load then leads to a reduction of the amount of sequences with strong antagonistic interactions between deleterious mutations in the population.
dc.description14 pages LaTeX, 3 eps figures, to appear in Proc. R. Soc. London B
dc.identifierhttps://arxiv.org/abs/physics/0007055
dc.identifierhttp://arxiv.org/abs/physics/0007055
dc.identifierProc. R. Soc. London B 268:1469-1474, 2001
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/83593
dc.subjectBiological Physics
dc.subjectSoft Condensed Matter
dc.subjectAdaptation and Self-Organizing Systems
dc.subjectPopulations and Evolution
dc.titleInteraction between directional epistasis and average mutational effects
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