Identification of specificity determining residues in enzymes using environment specific substitution tables
| dc.creator | Gore, Swanand | |
| dc.creator | Blundell, Tom | |
| dc.date | 2007-10-15 | |
| dc.date.accessioned | 2026-07-07T08:36:24Z | |
| dc.date.available | 2026-07-07T08:36:24Z | |
| dc.description | Environment specific substitution tables have been used effectively for distinguishing structural and functional constraints on proteins and thereby identify their active sites (Chelliah et al. (2004)). This work explores whether a similar approach can be used to identify specificity determining residues (SDRs) responsible for cofactor dependence, substrate specificity or subtle catalytic variations. We combine structure-sequence information and functional annotation from various data sources to create structural alignments for homologous enzymes and functional partitions therein. We develop a scoring procedure to predict SDRs and assess their accuracy using information from bound specific ligands and published literature. | |
| dc.identifier | https://arxiv.org/abs/0710.2808 | |
| dc.identifier | http://arxiv.org/abs/0710.2808 | |
| dc.identifier.uri | http://salesiana.dossiersoluciones.com/handle/123456789/140049 | |
| dc.subject | Quantitative Methods | |
| dc.title | Identification of specificity determining residues in enzymes using environment specific substitution tables | |
| dc.type | text |