Functionalized nanopore-embedded electrodes for rapid DNA sequencing

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dc.creatorHe, Haiying
dc.creatorScheicher, Ralph H.
dc.creatorPandey, Ravindra
dc.creatorRocha, Alexandre Reily
dc.creatorSanvito, Stefano
dc.creatorGrigoriev, Anton
dc.creatorAhuja, Rajeev
dc.creatorKarna, Shashi P.
dc.date2007-08-29
dc.date.accessioned2026-07-07T09:24:48Z
dc.date.available2026-07-07T09:24:48Z
dc.descriptionThe determination of a patient's DNA sequence can, in principle, reveal an increased risk to fall ill with particular diseases [1,2] and help to design "personalized medicine" [3]. Moreover, statistical studies and comparison of genomes [4] of a large number of individuals are crucial for the analysis of mutations [5] and hereditary diseases, paving the way to preventive medicine [6]. DNA sequencing is, however, currently still a vastly time-consuming and very expensive task [4], consisting of pre-processing steps, the actual sequencing using the Sanger method, and post-processing in the form of data analysis [7]. Here we propose a new approach that relies on functionalized nanopore-embedded electrodes to achieve an unambiguous distinction of the four nucleic acid bases in the DNA sequencing process. This represents a significant improvement over previously studied designs [8,9] which cannot reliably distinguish all four bases of DNA. The transport properties of the setup investigated by us, employing state-of-the-art density functional theory together with the non-equilibrium Green's Function method, leads to current responses that differ by at least one order of magnitude for different bases and can thus provide a much more robust read-out of the base sequence. The implementation of our proposed setup could thus lead to a viable protocol for rapid DNA sequencing with significant consequences for the future of genome related research in particular and health care in general.
dc.description12 pages, 5 figures
dc.identifierhttps://arxiv.org/abs/0708.4011
dc.identifierhttp://arxiv.org/abs/0708.4011
dc.identifierJ. Phys. Chem. C, 112 (10), 3456 -3459, 2008.
dc.identifierdoi:10.1021/jp7115142
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/156195
dc.subjectBiological Physics
dc.subjectSoft Condensed Matter
dc.subjectBiomolecules
dc.titleFunctionalized nanopore-embedded electrodes for rapid DNA sequencing
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