Theory of DNA translocation through narrow ion channels and nanopores with charged walls
| dc.creator | Hu, Tao | |
| dc.creator | Shklovskii, B. I. | |
| dc.date | 2008-03-04 | |
| dc.date | 2008-06-20 | |
| dc.date.accessioned | 2026-07-07T10:01:33Z | |
| dc.date.available | 2026-07-07T10:01:33Z | |
| dc.description | Translocation of a single stranded DNA through genetically engineered $α$-hemolysin channels with positively charged walls is studied. It is predicted that transport properties of such channels are dramatically different from neutral wild type $α$-hemolysin channel. We assume that the wall charges compensate the fraction $x$ of the bare charge $q_{b}$ of the DNA piece residing in the channel. Our prediction are as follows (i) At small concentration of salt the blocked ion current decreases with $x$. (ii) The effective charge $q$ of DNA piece, which is very small at $x = 0$ (neutral channel) grows with $x$ and at $x=1$ reaches $q_{b}$. (iii) The rate of DNA capture by the channel exponentially grows with $x$. Our theory is also applicable to translocation of a double stranded DNA in narrow solid state nanopores with positively charged walls. | |
| dc.description | 3 pages, 1 figure | |
| dc.identifier | https://arxiv.org/abs/0803.0483 | |
| dc.identifier | http://arxiv.org/abs/0803.0483 | |
| dc.identifier | Phys. Rev. E 78, 032901 (2008) | |
| dc.identifier | doi:10.1103/PhysRevE.78.032901 | |
| dc.identifier.uri | http://salesiana.dossiersoluciones.com/handle/123456789/168665 | |
| dc.subject | Subcellular Processes | |
| dc.subject | Soft Condensed Matter | |
| dc.title | Theory of DNA translocation through narrow ion channels and nanopores with charged walls | |
| dc.type | text |