Genetic Variability of Splicing Sites
| dc.creator | Parkhomchuk, Dmitri | |
| dc.date | 2006-11-17 | |
| dc.date | 2006-12-19 | |
| dc.date.accessioned | 2026-07-07T07:36:08Z | |
| dc.date.available | 2026-07-07T07:36:08Z | |
| dc.description | Splicing sites provide unique statistics in human genome due to their large number and reasonably complete annotation. Analyses of the cumulative SNPs distribution in splicing sites reveal a few interesting observations. While a degree of the nucleotide conservation reflects on the SNPs density monotonically, no detectable changes in the SNPs frequencies spectrum were found. Semi-conserved nucleotide sites harbor transition mutations predominantly. We propose that such transition preference is caused by co-evolution of a site with corresponding binding agents. Since transitions in humans and similarly in other organisms are almost twice as frequent as transversions, this adaptation significantly lowers the mutation load. | |
| dc.description | 4 pages 4 figures, grammatical revision | |
| dc.identifier | https://arxiv.org/abs/q-bio/0611060 | |
| dc.identifier | http://arxiv.org/abs/q-bio/0611060 | |
| dc.identifier.uri | http://salesiana.dossiersoluciones.com/handle/123456789/120323 | |
| dc.subject | Genomics | |
| dc.title | Genetic Variability of Splicing Sites | |
| dc.type | text |